Biodegradable supramolecular micelles via host-guest interaction of cyclodextrin-terminated polypeptides and adamantane-terminated polycaprolactones

Sharafudheen Pottanam Chali; Suna Azhdari; Anzhela Galstyan; André H Gröschel; Bart Jan Ravoo

doi:10.1039/d1cc03372g

Biodegradable supramolecular micelles via host-guest interaction of cyclodextrin-terminated polypeptides and adamantane-terminated polycaprolactones

Chem Commun (Camb). 2021 Sep 16;57(74):9446-9449. doi: 10.1039/d1cc03372g.

Authors

Sharafudheen Pottanam Chali¹, Suna Azhdari², Anzhela Galstyan³, André H Gröschel², Bart Jan Ravoo¹

Affiliations

¹ Organic Chemistry Institute and Centre for Soft Nanoscience Westfälische Wilhelms-Universität Münster, Corrensstrasse 36, 48149 Münster, Germany. [email protected].
² Physical Chemistry Institute and Centre for Soft Nanoscience Westfälische Wilhelms-Universität Münster, Corrensstrasse 28, 48149 Münster, Germany.
³ Centre for Soft Nanoscience Westfälische Wilhelms-Universität Münster, Busso-Peus-Strasse 10, 48149 Münster, Germany.

PMID: 34528969
DOI: 10.1039/d1cc03372g

Abstract

Biodegradable supramolecular micelles were prepared exploiting the host-guest interaction of cyclodextrin and adamantane. Cyclodextrin-initiated polypeptides acted as the hydrophilic corona, whereas adamantane-terminated polycaprolactones served as the hydrophobic core.

MeSH terms

Adamantane / chemistry*
Cyclodextrins / chemistry*
Hydrophobic and Hydrophilic Interactions
Macromolecular Substances / chemistry
Micelles
Molecular Structure
Peptides / chemistry*
Polyesters / chemistry*

Substances

Cyclodextrins
Macromolecular Substances
Micelles
Peptides
Polyesters
polycaprolactone
Adamantane