Expression of miR-92a in colon cancer tissues and its correlation with clinicopathologic features and prognosis

Objective: This study analyzed the expression of miR-92a in colon tumor tissues and its correlation with disease clinicopathologic features and prognosis.

Methods: 83 cases of colorectal cancer tissues and paracancerous normal tissues acquired from colon cancer resection surgery during January 2015-January 2017 were collected. We detected the expression of miR-92a in cancer tissues and paracancerous tissues by qRT-PCR, and analyzed the correlation between the relative expression of miR-92 in colon cancer tissues and clinicopathologic characteristics, progression-free survival (PFS), and overall survival (OS) of the patients accordingly.

Results: The relative expression level of miR-92a in colon cancer tissues was higher than of paracancerous tissues (P<0.05). Relative expression of miR-92a in cancer was correlated with the degree of differentiation, TNM stage, and lymph node metastasis (P<0.05), while uncorrelated with gender, age, tumor diameter, or invasion depth (P>0.05). Patients with low expression of miR-92a had superior PFS to the control group (P>0.05) and better OS (P<0.05).

Conclusion: Abnormally high expression of miR-92a occurs in colon tumor tissues. Its expression is related to the occurrence, progression, and prognosis of patients with colon cancer. It may be a marker for diagnosis, treatment, and prognosis of disease.