Coinfection between SARS-CoV-2 and vector-borne diseases in Luanda, Angola

J Med Virol. 2022 Jan;94(1):366-371. doi: 10.1002/jmv.27354. Epub 2021 Sep 27.

Abstract

Co-epidemics happening simultaneously can generate a burden on healthcare systems. The co-occurrence of SARS-CoV-2 with vector-borne diseases (VBD), such as malaria and dengue in resource-limited settings represents an additional challenge to the healthcare systems. Herein, we assessed the coinfection rate between SARS-CoV-2 and VBD to highlight the need to carry out an accurate diagnosis and promote timely measures for these infections in Luanda, the capital city of Angola. This was a cross-sectional study conducted with 105 subjects tested for the SARS-CoV-2 and VBD with a rapid detection test in April 2021. The participants tested positive for SARS-CoV-2 (3.80%), malaria (13.3%), and dengue (27.6%). Low odds related to testing positivity to SARS-CoV-2 or VBD were observed in participants above or equal to 40 years (odds ratio [OR]: 0.60, p = 0.536), while higher odds were observed in male (OR: 1.44, p = 0.392) and urbanized areas (OR: 3.78, p = 0.223). The overall co-infection rate between SARS-CoV-2 and VBD was 11.4%. Our findings showed a coinfection between SARS-CoV-2 with malaria and dengue, which could indicate the need to integrate the screening for VBD in the SARS-CoV-2 testing algorithm and the adjustment of treatment protocols. Further studies are warranted to better elucidate the relationship between COVID-19 and VBD in Angola.

Keywords: Angola; COVID-19; Luanda; SARS-CoV-2; coinfection; dengue; malaria; vector-borne diseases.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Angola / epidemiology
  • Antibodies, Protozoan / blood
  • Antibodies, Viral / blood
  • COVID-19 / epidemiology*
  • COVID-19 Testing
  • Chikungunya Fever / epidemiology
  • Child
  • Child, Preschool
  • Coinfection / epidemiology*
  • Cross-Sectional Studies
  • Dengue / epidemiology*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Malaria / epidemiology*
  • Male
  • Mass Screening
  • Middle Aged
  • RNA, Viral / blood
  • SARS-CoV-2 / isolation & purification
  • Sex Factors
  • Vector Borne Diseases / epidemiology*
  • Young Adult
  • Zika Virus Infection / epidemiology

Substances

  • Antibodies, Protozoan
  • Antibodies, Viral
  • RNA, Viral