Heterologous Hyperimmune Polyclonal Antibodies Against SARS-CoV-2: A Broad Coverage, Affordable, and Scalable Potential Immunotherapy for COVID-19

Alberto Alape-Girón; Andrés Moreira-Soto; Mauricio Arguedas; Hebleen Brenes; Willem Buján; Eugenia Corrales-Aguilar; Cecilia Díaz; Ann Echeverri; Marietta Flores-Díaz; Aarón Gómez; Andrés Hernández; María Herrera; Guillermo León; Román Macaya; José Arturo Molina-Mora; Javier Mora; Aarthi Narayanan; Alfredo Sanabria; Andrés Sánchez; Laura Sánchez; Álvaro Segura; Eduardo Segura; Daniela Solano; Claudio Soto; Jennifer L Stynoski; Mariángela Vargas; Mauren Villalta; Jan Felix Drexler; José María Gutiérrez

doi:10.3389/fmed.2021.743325

Heterologous Hyperimmune Polyclonal Antibodies Against SARS-CoV-2: A Broad Coverage, Affordable, and Scalable Potential Immunotherapy for COVID-19

Front Med (Lausanne). 2021 Sep 6:8:743325. doi: 10.3389/fmed.2021.743325. eCollection 2021.

Authors

Alberto Alape-Girón^{1

2}, Andrés Moreira-Soto³, Mauricio Arguedas¹, Hebleen Brenes⁴, Willem Buján^{2

5}, Eugenia Corrales-Aguilar⁶, Cecilia Díaz^{1

2}, Ann Echeverri⁵, Marietta Flores-Díaz¹, Aarón Gómez¹, Andrés Hernández¹, María Herrera¹, Guillermo León¹, Román Macaya⁵, José Arturo Molina-Mora⁶, Javier Mora⁶, Aarthi Narayanan⁷, Alfredo Sanabria⁵, Andrés Sánchez¹, Laura Sánchez¹, Álvaro Segura¹, Eduardo Segura¹, Daniela Solano¹, Claudio Soto⁴, Jennifer L Stynoski¹, Mariángela Vargas¹, Mauren Villalta¹, Jan Felix Drexler³, José María Gutiérrez¹

Affiliations

¹ Instituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
² School of Medicine University of Costa Rica, San Pedro, Costa Rica.
³ Institute of Virology, Charité Medical University of Berlin, Berlin, Germany.
⁴ Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, Ministry of Health, Cartago, Costa Rica.
⁵ Caja Costarricense del Seguro Social, San Jose, Costa Rica.
⁶ Research Center for Tropical Diseases, School of Microbiology, University of Costa Rica, San Pedro, Costa Rica.
⁷ National Center for Biodefense and Infectious Diseases, College of Science, George Mason University, Fairfax, VA, United States.

No abstract available

Keywords: COVID-19; SARS-CoV-2; convalescent plasma; heterologous antibodies; hyperimmune polyclonal antibodies; monoclonal antibodies; passive immunotherapy.