The global epidemic of COVID-19, social isolation and the fear of viral contagion have determined and determine profound changes in social relations between people. The purpose of this research, carried out online on published scientific studies, on information from magazines, accredited websites, books and newspapers, was to consider the possible interactions between the lockdown, the use of video games and the Internet Gaming Disorder. during the pandemic. The conclusions are an undoubtedly beneficial interaction for the psychophysical health of the users and the improvement of anxiety, stress and socialization with the help of video games during the pandemic. However, it is necessary to pay attention to the excessive, protracted and constant use of videogame activity, abuse and possible addiction, in particular for adolescents with previous psychological discomforts and pathologies such as depression, anxiety and stress. Parents are advised to pay attention to the time their children spend playing video games.