Regulation of IL-17A-Producing Cells in Skin Inflammatory Disorders

Pushpa Pandiyan; Thomas S McCormick

doi:10.1016/j.jid.2021.06.036

Regulation of IL-17A-Producing Cells in Skin Inflammatory Disorders

J Invest Dermatol. 2022 Mar;142(3 Pt B):867-875. doi: 10.1016/j.jid.2021.06.036. Epub 2021 Sep 22.

Authors

Pushpa Pandiyan¹, Thomas S McCormick²

Affiliations

¹ Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio, USA; Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA. Electronic address: [email protected].
² Department of Dermatology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

PMID: 34561088
DOI: 10.1016/j.jid.2021.06.036

Abstract

This review focuses on the IL-17A family of cytokines produced by T lymphocytes and other immune cells and how they are involved in cutaneous pathogenic responses. It will also discuss cutaneous dysbiosis and FOXP3⁺ regulatory T cells in the context of inflammatory conditions linked to IL-17 responses in the skin. Specifically, it will review key literature on chronic mucocutaneous candidiasis and psoriasis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Candidiasis, Chronic Mucocutaneous*
Humans
Interleukin-17
Psoriasis*
Skin
T-Lymphocytes, Regulatory

Substances

Interleukin-17

Grants and funding

P50 AR070590/AR/NIAMS NIH HHS/United States