Association of Bacterial Vaginosis With Higher Vaginal Indole Levels

Jyoti Sharma; Kanupriya Gupta; Jane R Schwebke; William M Geisler; Christina A Muzny

doi:10.1097/OLQ.0000000000001564

Association of Bacterial Vaginosis With Higher Vaginal Indole Levels

Sex Transm Dis. 2022 Mar 1;49(3):e53-e55. doi: 10.1097/OLQ.0000000000001564.

Authors

Jyoti Sharma¹, Kanupriya Gupta, Jane R Schwebke, William M Geisler, Christina A Muzny

Affiliation

¹ From the Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.

PMID: 34561371
DOI: 10.1097/OLQ.0000000000001564

Abstract

We adapted a simple hydroxylamine-based indole assay to detect indole from stored vaginal swab specimens from women with and without bacterial vaginosis (BV). Women with BV had significantly higher vaginal indole levels compared with women without BV (6451.5 vs 5632.4 μM; P = 0.01), suggesting that indole-producing bacteria are a component of BV.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacteria
Female
Humans
Indoles
Vagina / microbiology
Vaginosis, Bacterial* / diagnosis

Substances

Indoles