Associations of perinatal exposure to PM_2.5 with gestational weight gain and offspring birth weight

Background: PM_2.5 have been associated with weight change in animal models and non-pregnant populations. Evidence of associations between PM_2.5 and gestational weight gain (GWG), an important determinant of course and outcomes of pregnancy, and subsequent birth outcomes is limited.

Methods: The study was conducted among a subset of participants from the Omega Study, a prospective pregnancy cohort. Exposure to PM_2.5 (μg/m³) was ascertained for participants (N = 855) based on their residential address using a validated national spatiotemporal model. Adjusted multivariable linear regression models were used to estimate associations of trimester-specific and pregnancy-month PM_2.5 exposures with early (<20 weeks gestation), late (≥20 weeks gestation), and total GWG and infant birth weight. Stratified models and product terms were used to examine whether pre-pregnancy BMI (ppBMI) and infant sex modified the associations.

Results: Average monthly PM_2.5 exposure during the first, second, and third trimesters were 7.3 μg/m³, 7.9 μg/m³, and 7.7 μg/m³, respectively. Higher third trimester PM_2.5 exposure was associated with higher late (0.40 kg per 5 μg/m (McDowell et al., 2018); 95%CI: 0.12, 0.67) and total (0.35 kg; 95%CI: 0.01, 0.70) GWG among participants with normal ppBMI. Higher second month PM_2.5 exposure was associated with lower early (-0.70 kg; 95%CI: 1.22, -0.18), late (-0.84 kg; 95% CI: 1.54, -0.14), and total (-1.70 kg; 95%CI: 2.57, -0.82) GWG among participants with overweight/obese ppBMI. Product terms between PM_2.5 and ppBMI were significant for second month PM_2.5 exposure and early (p-value = 0.01) and total GWG (p-value<0.01). Higher third trimester PM_2.5 exposure was associated with higher birth weight, though higher fourth month PM_2.5 exposure was associated with lower birth weight, particularly among those with normal ppBMI and male infants.

Conclusions: Associations of PM_2.5 with GWG vary by exposure window and ppBMI, while associations of PM_2.5 with birth weight potentially vary by exposure window, ppBMI and infant sex. Further exploration of associations between PM_2.5 and maternal/child health outcomes are needed.