IgA nephropathy in IgG kappa multiple myeloma

Maria Eduarda Couto; Domingos Sousa; Hugo Ferreira; Alda Tavares; Isabel Oliveira; Nelson Domingues; Ana Paiva; Teresa Chuva; José Maximino; Rui Manuel Ferreira Henrique; José Mário Mariz

doi:10.1097/j.pbj.0000000000000142

IgA nephropathy in IgG kappa multiple myeloma

Porto Biomed J. 2021 Oct 11;6(5):e142. doi: 10.1097/j.pbj.0000000000000142. eCollection 2021 Sep-Oct.

Affiliations

¹ Onco-hematology Department, Instituto Português de Oncologia do Porto, FG, EPE.
² Internal Medicine Department, Centro Hospitalar e Universitário do Algarve, EPE.
³ Nephrology Department, Instituto Português de Oncologia do Porto, FG, EPE.
⁴ Oncology Department, Hospital Pedro Hispano, EPE.
⁵ Department of Pathology and Molecular Immunology, Instituto Português de Oncologia do Porto, FG, EPE; Biomedical Sciences, Institute of Abel Salazar, University of Porto, Portugal.

Abstract

Multiple myeloma (MM) frequently affects kidney function through multiple mechanisms. Nonetheless, some patients develop kidney injury due to other causes. A 54-year-old woman was diagnosed with IgG kappa MM developed IgA nephropathy without cast nephropathy. Further studies did not show criteria for MM progression or other causes. This case highlights the need for further investigation of kidney injury in MM patients (such as toxicity of previous drugs, infectious events, or immune-mediated disorders).

Keywords: IgA nephropathy; acute kidney injury; corticosteroids; multiple myeloma; purpura.