Durable Response to Larotrectinib in a Child With Histologic Diagnosis of Recurrent Disseminated Ependymoma Discovered to Harbor an NTRK2 Fusion: The Impact of Integrated Genomic Profiling

JCO Precis Oncol. 2021 Jul 28:5:PO.20.00375. doi: 10.1200/PO.20.00375. eCollection 2021.

Ross Mangum¹, Jacquelyn Reuther², Kelsey C Bertrand¹, Raghu Chandramohan³, Marcia K Kukreja⁴, Arnold C Paulino⁵, Donna Muzny^{3

6}, Jianhong Hu^{3

6}, Richard A Gibbs^{3

6}, Daniel J Curry⁷, Fatema Malbari^{1

8}, Murali M Chintagumpala^{1

9}, Adekunle M Adesina^{2

9

10}, Kevin E Fisher^{2

9

10}, Stephen C Mack^{1

9}, Sharon E Plon^{1

3

6

9}, Angshumoy Roy^{1

2

9

10}, D Williams Parsons^{1

3

6

9}, Frank Y Lin^{1

9}

¹ Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX.
² Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX.
³ Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
⁴ Department of Radiology, Texas Children's Hospital, Houston, TX.
⁵ Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX.
⁶ The Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
⁷ Division of Pediatric Neurosurgery, Department of Neurosurgery, Baylor College of Medicine, Houston, TX.
⁸ Division of Pediatric Neurology and Developmental Neurosciences, Department of Pediatrics, Texas Children's Hospital, Houston, TX.
⁹ The Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX.
¹⁰ Department of Pathology, Texas Children's Hospital, Houston, TX.

No abstract available

Publication types