Astronomical observations and isotopic measurements of meteorites suggest that substructures are common in protoplanetary disks and may even have existed in the solar nebula. Here, we conduct paleomagnetic measurements of chondrules in CO carbonaceous chondrites to investigate the existence and nature of these disk substructures. We show that the paleomagnetism of chondrules in CO carbonaceous chondrites indicates the presence of a 101 ± 48 μT field in the solar nebula in the outer solar system (~3 to 7 AU from the Sun). The high intensity of this field relative to that inferred from inner solar system (~<3 AU) meteorites indicates a factor of ~5 to 150 mismatch in nebular accretion between the two reservoirs. This suggests substantial mass loss from the disk associated with a major disk substructure, possibly due to a magnetized disk wind.