Diethylaminosulfur Trifluoride: A Novel, Low-Cost, Stable Double Thiolation Reagent for Imidazo[1,2-α]pyridines

Hongmei Jiang; Haicheng Shen; Sha Zhu; Binbin Wang; Yujie Yang; Zhibin Nong; Min Yi; Shiyun Tang; Qing-Wen Gui

doi:10.1021/acsomega.1c03291

Diethylaminosulfur Trifluoride: A Novel, Low-Cost, Stable Double Thiolation Reagent for Imidazo[1,2-α]pyridines

ACS Omega. 2021 Sep 28;6(40):26273-26281. doi: 10.1021/acsomega.1c03291. eCollection 2021 Oct 12.

Authors

Hongmei Jiang^{1

2}, Haicheng Shen¹, Sha Zhu¹, Binbin Wang¹, Yujie Yang¹, Zhibin Nong¹, Min Yi¹, Shiyun Tang^{1

3}, Qing-Wen Gui^{1

2}

Affiliations

¹ College of Chemistry and Materials Science, Hunan Agricultural University, Changsha 410128, People's Republic of China.
² State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China.
³ China Yunnan Key Laboratory of Tobacco Chemistry, Research and Development Center, China Tobacco Yunnan Industrial Company, Kunming 650231, People's Republic of China.

Abstract

We report a novel, inexpensive double thiolation reagent that sulfurizes a broad range of imidazo[1,2-α]pyridines under mild conditions. Importantly, diethylaminosulfur trifluoride, as a common nucleophilic fluorinating reagent, was utilized as a novel thiolation reagent.