Moderating effect of ppar-γ on the association of c-reactive protein and ischemic stroke in patients younger than 60

A Bazina Martinović; A Merkler; I Ćelić; K Starčević; M Šimić; I Karmelić; Z Poljaković; D Kalinić; J Sertić

doi:10.1016/j.gene.2021.146029

Moderating effect of ppar-γ on the association of c-reactive protein and ischemic stroke in patients younger than 60

Gene. 2022 Jan 30:809:146029. doi: 10.1016/j.gene.2021.146029. Epub 2021 Oct 18.

Authors

A Bazina Martinović¹, A Merkler², I Ćelić³, K Starčević⁴, M Šimić⁵, I Karmelić⁶, Z Poljaković⁷, D Kalinić⁸, J Sertić⁹

Affiliations

¹ Department of Neurology, University Hospital Centre Zagreb, Zagreb, Croatia. Electronic address: [email protected].
² Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia. Electronic address: [email protected].
³ Department of Dual Diagnosis, University Psychiatric Hospital Vrapče, Zagreb, Croatia. Electronic address: [email protected].
⁴ Department of Neurology, University Hospital Centre Zagreb, Zagreb, Croatia.
⁵ Department of Clinical Microbiology, Andrija Štampar Teaching Institute of Public Health, Zagreb, Croatia. Electronic address: [email protected].
⁶ University of Zagreb, School of Medicine, Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Zagreb, Croatia. Electronic address: [email protected].
⁷ Department of Neurology, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia.
⁸ Department of Biological Psychiatry and Psychogeriatrics, University Psychiatric Hospital Vrapče, Zagreb, Croatia.
⁹ Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb, School of Medicine, Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Zagreb, Croatia. Electronic address: [email protected].

PMID: 34673211
DOI: 10.1016/j.gene.2021.146029

Abstract

Aim: The aim of this study was to evaluate the moderating effect of peroxisome proliferator activated receptor-γ (PPAR-γ) gene variants on the association of serum C-reactive protein level (CRP) and ischemic stroke (IS).

Material and methods: A total of 114 patients with IS and 135 healthy controls were included.

Results: After adjustment for age, sex, total cholesterol, LDL and HDL cholesterol, triglycerides, hypertension, smoking, body mass index and previous therapy with antihypertensive and/or statins, PPAR-γ had statistically significant moderating effect on association of serum CRP level and IS in patients younger than 60. In participants with PPAR CG or GG genotype level of CRP and IS were not statistically significantly associated (OR = 1.00; 95% CI 0.90-1.10; p = 0.933), but in participants with PPAR CC genotype, the association of serum CRP level and IS was significant (OR = 1.67; 95% CI 1.21-2.31; p = 0.002).

Conclusion: In patients with PPAR CC genotype the association of serum CRP level and IS was significant.

Keywords: Ischemic stroke; PPAR CC genotype; serum CRP level.

MeSH terms

C-Reactive Protein / analysis*
Case-Control Studies
Female
Genotype
Humans
Ischemic Stroke / blood
Ischemic Stroke / genetics*
Male
Middle Aged
PPAR gamma / genetics*

Substances

PPAR gamma
PPARG protein, human
C-Reactive Protein