Infant serotype specific anti-capsular immunoglobulin G antibody and risk of invasive group B Streptococcal disease

Ziyaad Dangor; Gaurav Kwatra; Alane Izu; Mahtaab Khan; Sanjay G Lala; Shabir A Madhi

doi:10.1016/j.vaccine.2021.10.022

Infant serotype specific anti-capsular immunoglobulin G antibody and risk of invasive group B Streptococcal disease

Vaccine. 2021 Nov 16;39(47):6813-6816. doi: 10.1016/j.vaccine.2021.10.022. Epub 2021 Oct 20.

Authors

Ziyaad Dangor¹, Gaurav Kwatra², Alane Izu³, Mahtaab Khan⁴, Sanjay G Lala⁴, Shabir A Madhi⁵

Affiliations

¹ South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, South Africa; Department of Paediatrics & Child Health, Faculty of Health Sciences, University of the Witwatersrand, South Africa. Electronic address: [email protected].
² South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, South Africa; Department of Clinical Microbiology, Christian Medical College, Vellore, India.
³ South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, South Africa.
⁴ Department of Paediatrics & Child Health, Faculty of Health Sciences, University of the Witwatersrand, South Africa.
⁵ South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, South Africa; African Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

PMID: 34688499
DOI: 10.1016/j.vaccine.2021.10.022

Abstract

Past studies have mainly investigated the association of serotype-specific capsular IgG in the mother and risk reduction of invasive Group B Streptococcus (GBS) in their young infants. The efficiency of transplacental transfer of IgG could be affected by multiple maternal factors. Hence, investigation of infant serum GBS anti-capsular IgG and risk reduction for invasive GBS disease may be more robust and generalizable. In a matched case-control study, infant serum serotype-specific capsular polysaccharide Ia and III IgG concentrations were analyzed in infants with invasive GBS cases and healthy controls born to women with recto-vaginal colonization by the homotypic serotype. Using Bayesian modeling, an antibody concentration of 2.5 µg/mL and 1 µg/mL predicted a 90% reduced risk of invasive disease for serotype Ia and III, respectively. These data contribute to the possible licensure of a GBS polysaccharide-protein conjugate vaccine, targeted at pregnant women, based on serological correlates of protection against invasive GBS disease.

Keywords: Antibodies; Group B Streptococcus; Maternal vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Bacterial*
Bayes Theorem
Case-Control Studies
Female
Humans
Immunoglobulin G
Infant
Pregnancy
Serogroup
Streptococcal Infections* / prevention & control
Streptococcus agalactiae

Substances

Antibodies, Bacterial
Immunoglobulin G