Succinate dehydrogenase deficient renal cell carcinoma: A case report

Raj A Kumar; Hiroko Miyagi; Vimal Mittal; Paul Crispen; Udaya Kumar

doi:10.1016/j.eucr.2021.101885

Succinate dehydrogenase deficient renal cell carcinoma: A case report

Urol Case Rep. 2021 Oct 12:40:101885. doi: 10.1016/j.eucr.2021.101885. eCollection 2022 Jan.

Authors

Raj A Kumar¹, Hiroko Miyagi², Vimal Mittal³, Paul Crispen², Udaya Kumar³

Affiliations

¹ Catherine & Joseph Aresty Department of Urology, Keck Medicine of USC, University of Southern California, Los Angeles, CA, USA.
² Department of Urology, University of Florida College of Medicine, University of Florida, Gainesville, FL, USA.
³ Citrus Memorial Hospital, Inverness, FL, USA.

Abstract

Succinate dehydrogenase (SDH) deficient renal cell carcinoma (RCC) are uncommon renal tumors that typically present in relatively younger patients. SDH mutations are known to cause cancer, but often presents with hereditary paragangliomas, pheochromocytomas, and gastrointestinal stromal tumors. This report details a case of SDH deficient RCC in a patient with no know contributing family history. Patient presented with recurrent urinary tract infections and groin pain. Computerized tomography (CT) revealed a 4 cm mass in the right kidney. Partial nephrectomy was performed, and the patient had an uneventful recovery. Immunohistochemical staining revealed the tumor was SDH negative.

Keywords: Partial nephrectomy; Renal cancer; Renal cell carcinoma; Succinate dehydrogenase.

Publication types

Case Reports