The cannabinoid WIN55212-2 suppresses effector T-cell responses and promotes regulatory T cells in human tonsils

Allergy. 2022 Mar;77(3):1029-1032. doi: 10.1111/all.15160. Epub 2021 Nov 7.

Authors

Alba Angelina¹, Mario Pérez-Diego¹, Angel Maldonado¹, Beate Rückert², Mübeccel Akdis², Mar Martín-Fontecha³, Cezmi A Akdis², Oscar Palomares¹

Affiliations

¹ Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, Madrid, Spain.
² Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Davos, Switzerland.
³ Department of Organic Chemistry, School of Optics and Optometry, Complutense University of Madrid, Madrid, Spain.

PMID: 34713459
DOI: 10.1111/all.15160

No abstract available

Keywords: cannabinoids; effector T cells; regulatory T cells; tonsils.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Benzoxazines
Cannabinoids* / pharmacology
Humans
Morpholines
Naphthalenes
Palatine Tonsil
Receptor, Cannabinoid, CB1
T-Lymphocytes, Regulatory

Substances

Benzoxazines
Cannabinoids
Morpholines
Naphthalenes
Receptor, Cannabinoid, CB1
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone