Detection and sequencing of Zika virus in normocephalic newborns with congenital Zika infection

Int J Infect Dis. 2022 Jan:114:128-131. doi: 10.1016/j.ijid.2021.10.051. Epub 2021 Oct 30.

Abstract

Fourteen asymptomatic normocephalic newborns with confirmed congenital Zika infection were investigated. All newborns presented Zika virus (ZIKV) positivity on reverse transcriptase polymerase chain reaction. Following ZIKV-specific NS5 gene fragment sequencing in one child, phylogenetic analysis revealed that this isolate belonged to the Asian genotype, and clustered closely with other sequences previously isolated in north-east and northern regions of Brazil.

Keywords: Congenital infection; Phylogenetic analysis; Viral sequencing; Zika virus.

Publication types

  • Case Reports

MeSH terms

  • Brazil
  • Craniosynostoses*
  • Female
  • Humans
  • Infant, Newborn
  • Phylogeny
  • Pregnancy
  • Pregnancy Complications, Infectious*
  • Zika Virus Infection* / diagnosis
  • Zika Virus Infection* / epidemiology
  • Zika Virus* / genetics