Intestinal metaplasia is a precursor lesion for sinonasal intestinal-type adenocarcinoma: genomic investigation of a case proving this hypothesis

APMIS. 2022 Jan;130(1):53-56. doi: 10.1111/apm.13187. Epub 2021 Nov 25.
No abstract available

Keywords: DNA-mutations; Sinonasal cancer; Sinonasal intestinal-type adenocarcinoma; genomics; metaplasia.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adenocarcinoma / diagnosis*
  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology
  • Adenocarcinoma / surgery
  • Aged
  • Biomarkers, Tumor / genetics*
  • Biomarkers, Tumor / metabolism
  • CDX2 Transcription Factor / genetics
  • CDX2 Transcription Factor / metabolism
  • Cyclin-Dependent Kinase Inhibitor p16 / genetics
  • Cyclin-Dependent Kinase Inhibitor p16 / metabolism
  • Gene Expression
  • Humans
  • Immunohistochemistry
  • Intestinal Neoplasms / diagnosis*
  • Intestinal Neoplasms / genetics
  • Intestinal Neoplasms / pathology
  • Intestinal Neoplasms / surgery
  • Intestines / metabolism
  • Intestines / pathology
  • Keratin-20 / genetics
  • Keratin-20 / metabolism
  • Lymph Nodes / pathology
  • Lymph Nodes / surgery
  • Male
  • Metaplasia / diagnosis*
  • Metaplasia / genetics
  • Metaplasia / pathology
  • Metaplasia / surgery
  • Paranasal Sinuses / metabolism
  • Paranasal Sinuses / pathology*
  • Paranasal Sinuses / surgery

Substances

  • Biomarkers, Tumor
  • CDKN2A protein, human
  • CDX2 Transcription Factor
  • CDX2 protein, human
  • Cyclin-Dependent Kinase Inhibitor p16
  • KRT20 protein, human
  • Keratin-20