An evidence map of treatments for infantile epilepsy

Eric A Apaydin; Arthur Partikian; Julia Rollison; Sangita Baxi; Ning Fu; Susanne Hempel

doi:10.1016/j.eplepsyres.2021.106781

An evidence map of treatments for infantile epilepsy

Epilepsy Res. 2021 Dec:178:106781. doi: 10.1016/j.eplepsyres.2021.106781. Epub 2021 Oct 28.

Authors

Eric A Apaydin¹, Arthur Partikian², Julia Rollison³, Sangita Baxi⁴, Ning Fu⁵, Susanne Hempel⁶

Affiliations

¹ Southern California Evidence-based Practice Center, RAND Corporation, Santa Monica, CA, 90401, United States; Center for the Study of Healthcare Innovation, Implementation and Policy, VA Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, United States. Electronic address: [email protected].
² Departments of Pediatrics & Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, United States.
³ Southern California Evidence-based Practice Center, RAND Corporation, Arlington, VA, 22202, United States.
⁴ Southern California Evidence-based Practice Center, RAND Corporation, Santa Monica, CA, 90401, United States.
⁵ School of Economics, Shanghai University of Finance and Economics, Shanghai, China.
⁶ Southern California Evidence-based Practice Center, RAND Corporation, Santa Monica, CA, 90401, United States; Southern California Evidence Review Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, United States.

PMID: 34741993
DOI: 10.1016/j.eplepsyres.2021.106781

Abstract

Epilepsy prevalence is high among infants, but treatment guidelines are not clear. We conducted a scoping review of interventions to manage epilepsy in infants, and identified 37 studies. Most studies reported that interventions were effective (22 studies; 76 %), but randomized controlled trials were uncommon (7 studies; 19 %) and sample sizes were small (range: 2 to 284 participants; mean: 69.4; 95 % confidence interval: 49.5, 89.2). Additional high quality research and systematic reviews on interventions for infantile epilepsy are needed to establish better treatment guidelines for the disease.

Keywords: Epilepsy; Evidence map; Infants; Scoping review.

Published by Elsevier B.V.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Epilepsy* / epidemiology
Epilepsy* / therapy
Humans
Infant