Quantitative CT in mortality prediction in pulmonary fibrosis with or without emphysema

Fatma Üçsular; Gülistan Karadeniz; Gülru Polat; Enver Yalnız; Aysu Ayrancı; Akin Çinkooğlu; Recep Savaş; Hatice Solmaz; Filiz Güldaval; Melih Büyükşirin

doi:10.36141/svdld.v38i3.11044

Quantitative CT in mortality prediction in pulmonary fibrosis with or without emphysema

Sarcoidosis Vasc Diffuse Lung Dis. 2021;38(3):e2021024. doi: 10.36141/svdld.v38i3.11044. Epub 2021 Sep 30.

Affiliations

¹ University of Health Sciences, Dr Suat Seren Chest Disease and Surgery Training and Research Hospital, Pulmonary Disease, Izmir, Turkey.
² Ege University Medical Faculty, Radiology, Izmir, Turkey.
³ University of Health Sciencies, Tepecik Training and Research Hospital, Cardiology, Izmir, Turkey.

Abstract

Aim: We aimed to evaluate the quantitative CT analysis of patients with CPFE in comparison with IPF and emphysema.

Methods: Patients with CPFE(n:36), IPF(n:38) and emphysema(n:32) were retrospectively included in the study with the approval of the ethics committee.

Results: There was a positive correlation between total lung volume and FVC%, TLCO% and 6 MWT, and negative correlation between mMRC and mortality. Negative correlation was found between right, left lung density and FVC%, TLCO% and 6 MWT, and positive correlation between mortality. Also, total lung volume, right and left lung densities were significant in predicting mortality and cut-off values are ≤3831,> -778 and> -775, respectively (p = 0.040, 0.020, 0.013).

Conclusion: Quantitative CT are guiding in predicting mortality of the disease.

Keywords: Combined pulmonary fibrosis and emphysema; emphysema; idiopathic pulmonary fibrosis; pulmonary function test; quantitative computerized tomography.