Skeletal myoclonus in olivopontocerebellar atrophy: treatment with trihexyphenidyl

Neurology. 1987 Jul;37(7):1258-62. doi: 10.1212/wnl.37.7.1258.

Abstract

We studied two patients with nonfamilial olivopontocerebellar atrophy with skeletal myoclonus. Palatal or skeletal myoclonus is probably not a coincidental finding but another manifestation of the underlying disease. In both cases, the myoclonus was suppressed by administration of trihexyphenidyl, indicating a cholinergic disorder.

Publication types

  • Case Reports

MeSH terms

  • Brain / diagnostic imaging
  • Clonazepam / therapeutic use
  • Drug Therapy, Combination
  • Electromyography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscles / physiopathology
  • Myoclonus / drug therapy*
  • Myoclonus / etiology
  • Myoclonus / physiopathology
  • Olivopontocerebellar Atrophies / complications*
  • Olivopontocerebellar Atrophies / diagnostic imaging
  • Spinocerebellar Degenerations / complications*
  • Tomography, X-Ray Computed
  • Trihexyphenidyl / therapeutic use*

Substances

  • Clonazepam
  • Trihexyphenidyl