Immune reconstitution inflammatory syndrome (IRIS) in a patient with neuro pulmonary nocardiosis following hematopoietic cells transplantation (HCT)

Ivan Gur; Neta Petersiel; Amir Karban; Tzila Zuckerman; Ilana Oren; Anat Stern

doi:10.1016/j.jiac.2021.10.031

Immune reconstitution inflammatory syndrome (IRIS) in a patient with neuro pulmonary nocardiosis following hematopoietic cells transplantation (HCT)

J Infect Chemother. 2022 Feb;28(2):311-314. doi: 10.1016/j.jiac.2021.10.031. Epub 2021 Nov 18.

Authors

Ivan Gur¹, Neta Petersiel², Amir Karban³, Tzila Zuckerman⁴, Ilana Oren², Anat Stern⁵

Affiliations

¹ Department of Internal Medicine, Rambam Healthcare Campus, Haifa, Israel. Electronic address: [email protected].
² Infectious Disease Institute, Rambam Healthcare Campus, Haifa, Israel.
³ Department of Internal Medicine, Rambam Healthcare Campus, Haifa, Israel.
⁴ Hematology Department and Bone Marrow Transplantation Unit, Rambam Healthcare Campus, Haifa, Israel.
⁵ Department of Internal Medicine, Rambam Healthcare Campus, Haifa, Israel; Infectious Disease Institute, Rambam Healthcare Campus, Haifa, Israel. Electronic address: [email protected].

PMID: 34801397
DOI: 10.1016/j.jiac.2021.10.031

Abstract

Immune reconstitution inflammatory syndrome (IRIS) is increasingly reported in various HIV negative patients with immunosuppression, but the relationship with hematopoietic cell transplantation (HCT) is not well defined. We report a case of IRIS in a patient infected with pulmonary and CNS Nocardiosis following HCT due to primary myelofibrosis.

Keywords: Hematopoietic cells transplantation (HCT); Immune reconstitution inflammatory syndrome (IRIS); Invasive nocardiosis.

Publication types

Case Reports

MeSH terms

HIV Infections*
Hematopoietic Stem Cell Transplantation* / adverse effects
Humans
Immune Reconstitution Inflammatory Syndrome*
Nocardia Infections* / diagnosis