Antiretroviral therapies and corticosteroids: Drug-drug interactions

Nurse Pract. 2021 Dec 1;46(12):40-47. doi: 10.1097/01.NPR.0000798224.30305.d1.

Abstract

Antiretroviral therapies for HIV may cause systemic toxicities when coadministered with corticosteroids. Potential drug-drug interactions may occur, leading to iatrogenic Cushing syndrome or adrenal insufficiency. This article highlights the drug-drug interactions of antiretroviral therapies with corticosteroids. Practice implications are discussed.

MeSH terms

  • Adrenal Cortex Hormones / pharmacology
  • Adrenal Cortex Hormones / therapeutic use
  • Adrenal Insufficiency* / chemically induced
  • Adrenal Insufficiency* / drug therapy
  • Drug Interactions
  • HIV Infections* / drug therapy
  • Humans
  • Ritonavir / therapeutic use

Substances

  • Adrenal Cortex Hormones
  • Ritonavir