Vectorial Catalysis in Surface-Anchored Nanometer-Sized Metal-Organic Frameworks-Based Microfluidic Devices

Anna Lisa Semrau; Philip M Stanley; Dominik Huber; Michael Schuster; Bauke Albada; Han Zuilhof; Mirza Cokoja; Roland A Fischer

doi:10.1002/anie.202115100

Vectorial Catalysis in Surface-Anchored Nanometer-Sized Metal-Organic Frameworks-Based Microfluidic Devices

Angew Chem Int Ed Engl. 2022 Feb 14;61(8):e202115100. doi: 10.1002/anie.202115100. Epub 2021 Dec 9.

Authors

Anna Lisa Semrau¹, Philip M Stanley¹, Dominik Huber², Michael Schuster², Bauke Albada³, Han Zuilhof^{3

4

5}, Mirza Cokoja¹, Roland A Fischer¹

Affiliations

¹ Department of Chemistry, Inorganic and Metal-Organic Chemistry, Technical University of Munich, Lichtenbergstraße 4, 85787, Garching, Germany.
² Department of Chemistry, Analytical Chemistry, Technical University of Munich, Lichtenbergstraße 4, 85787, Garching, Germany.
³ Laboratory of Organic Chemistry, Wageningen University and Research, Stippeneng 4, 6708WE, Wageningen, The Netherlands.
⁴ School of Pharmaceutical Sciences and Technology, Tianjin University, 300072, Tianjin, China.
⁵ Department of Chemical and Materials Engineering, Faculty of Engineering, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.

Abstract

Vectorial catalysis-controlling multi-step reactions in a programmed sequence and by defined spatial localization in a microscale device-is an enticing goal in bio-inspired catalysis research. However, translating concepts from natural cascade biocatalysis into artificial hierarchical chemical systems remains a challenge. Herein, we demonstrate integration of two different surface-anchored nanometer-sized metal-organic frameworks (MOFs) in a microfluidic device for modelling vectorial catalysis. Catalyst immobilization at defined sections along the microchannel and a two-step cascade reaction was conducted with full conversion after 30 seconds and high turnover frequencies (TOF≈10⁵ h^-1 ).

Keywords: Catalysis; Metal-organic frameworks; Microfluidic devices; Surface anchoring; Vectorial catalysis.

Publication types

Research Support, Non-U.S. Gov't