Engineering nanoparticle therapeutics for impaired wound healing in diabetes

Yasmeen Shamiya; Shruthi Polla Ravi; Ali Coyle; Subrata Chakrabarti; Arghya Paul

doi:10.1016/j.drudis.2021.11.024

Engineering nanoparticle therapeutics for impaired wound healing in diabetes

Drug Discov Today. 2022 Apr;27(4):1156-1166. doi: 10.1016/j.drudis.2021.11.024. Epub 2021 Nov 25.

Authors

Yasmeen Shamiya¹, Shruthi Polla Ravi², Ali Coyle², Subrata Chakrabarti³, Arghya Paul⁴

Affiliations

¹ Department of Chemistry, The University of Western Ontario, London, ON N6A 5B9, Canada.
² School of Biomedical Engineering, The University of Western Ontario, London, ON N6A 5B9, Canada.
³ Department of Pathology and Laboratory Medicine, The University of Western Ontario, London, ON N6A 5B9, Canada.
⁴ Department of Chemistry, The University of Western Ontario, London, ON N6A 5B9, Canada; School of Biomedical Engineering, The University of Western Ontario, London, ON N6A 5B9, Canada; Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON N6A 5B9, Canada; The Centre for Advanced Materials and Biomaterials Research, The University of Western Ontario, London, ON N6A 5B7, Canada. Electronic address: [email protected].

PMID: 34839040
DOI: 10.1016/j.drudis.2021.11.024

Abstract

Diabetes mellitus is a chronic disease characterized by increased blood glucose levels, leading to damage of the nerves blood vessels, subsequently manifesting as organ failures, wounds, or ulcerations. Wounds in patients with diabetes are further complicated because of reduced cytokine responses, infection, poor vascularization, and delayed healing processes. Surface-functionalized and bioengineered nanoparticles (NPs) have recently gained attention as emerging treatment modalities for wound healing in diabetes. Here, we review emerging therapeutic NPs to treat diabetic wounds and highlight their discrete delivery mechanisms and sites of action. We further critically assess the current challenges of these nanoengineered materials for successful clinical translation and discuss their potential for growth in the clinical marketplace.

Keywords: Biomaterials; Drug delivery; Nanomedicine; Polymers; Regenerative medicine; Wound healing.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Diabetes Mellitus* / drug therapy
Humans
Nanoparticles*
Wound Healing

Grants and funding

CIHR/Canada