Chronic-Relapsing cutaneous leukocytoclastic vasculitis in a young patient with reduced EBV-specific T cell response using enzyme-linked immunospot (ELISPOT) assay successfully treated with Valaciclovir

Caterina Foti; Elvira Favoino; Maria Scarasciulli; Anna Maria Colacicco; Hamidreza Jahantigh; Angela Stufano; Piero Lovreglio; Paola Mascia; Chiara Barlusconi; Federico Perosa; Paolo Romita; Agata Calvario

doi:10.1016/j.idcr.2021.e01331

Chronic-Relapsing cutaneous leukocytoclastic vasculitis in a young patient with reduced EBV-specific T cell response using enzyme-linked immunospot (ELISPOT) assay successfully treated with Valaciclovir

IDCases. 2021 Nov 11:26:e01331. doi: 10.1016/j.idcr.2021.e01331. eCollection 2021.

Affiliations

¹ Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari "Aldo Moro", Bari, Italy.
² Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy.
³ Microbiology and Virology Unit - Interdisciplinary Department of Medicine (DIM) - University of Bari "Aldo Moro"- AOU Policlinico Bari, Italy.
⁴ Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.

Abstract

Among different pathogens, opportunistic viral infection caused by EBV is particularly relevant. This gammaherpesvirus, belonging to the Herpesviridae family, may complicate the disease course in different clinical settings by inducing pathological EBV pictures in patients with a defective immunologic response. Our report evaluated EBV-specific T cell responses by IFN- γ ELISPOT assay, which revealed defective EBV specific immunological response.

Publication types

Case Reports