Deciphering the genetic and epigenetic landscape of pediatric bithalamic tumors

Arnault Tauziède-Espariat; Marie-Anne Debily; David Castel; Jacques Grill; Stéphanie Puget; Alexandre Roux; Raphaël Saffroy; Guillaume Gauchotte; Ellen Wahler; Lauren Hasty; Fabrice Chrétien; Emmanuèle Lechapt; Volodia Dangouloff-Ros; Nathalie Boddaert; Philipp Sievers; Pascale Varlet

doi:10.1111/bpa.13039

Deciphering the genetic and epigenetic landscape of pediatric bithalamic tumors

Brain Pathol. 2022 May;32(3):e13039. doi: 10.1111/bpa.13039. Epub 2021 Dec 1.

Authors

Arnault Tauziède-Espariat¹, Marie-Anne Debily^{2

3}, David Castel^{2

4}, Jacques Grill^{2

4}, Stéphanie Puget⁵, Alexandre Roux⁶, Raphaël Saffroy⁷, Guillaume Gauchotte⁸, Ellen Wahler¹, Lauren Hasty¹, Fabrice Chrétien¹, Emmanuèle Lechapt¹, Volodia Dangouloff-Ros⁹, Nathalie Boddaert⁹, Philipp Sievers^{10

11}, Pascale Varlet¹

Affiliations

¹ Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, Paris, France.
² U981, Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
³ Univ. Evry, Université Paris-Saclay, Evry, France.
⁴ Department of Pediatric Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
⁵ Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cite, Paris, France.
⁶ Department of Neurosurgery, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, Paris, France.
⁷ Department of Biochemistry and Oncogenetic, Paul Brousse Hospital, Villejuif, France.
⁸ Department of Pathology, CHRU, Nancy, France.
⁹ Pediatric Radiology Department, Hôpital Necker Enfants Malades, AP-HP, University de Paris.
¹⁰ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
¹¹ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Abstract

Pediatric bithalamic gliomas encompass several histomolecular tumoral types from benign to malignant and underlines the central role of a comprehensive neuropathological review, including immunohistochemistry, genetic, and epigenetic analyses, to achieve an accurate diagnosis.

Keywords: bithalamic; landscape; pediatric..

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms* / pathology
Child
Epigenesis, Genetic
Epigenomics
Glioma* / genetics
Glioma* / pathology
Humans