METTLing in the right place: METTL8 is a mitochondrial tRNA-specific methyltransferase

Mol Cell. 2021 Dec 2;81(23):4765-4767. doi: 10.1016/j.molcel.2021.11.009.

Abstract

Schöller et al. (2021) discovered that METTL8, thought of as an mRNA modifier, is a tRNA-specific mitochondrial enzyme important for mitochondrial translation and function. Paradoxically, increased expression of METTL8 is associated with high respiratory rates in pancreatic cancers.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Mitochondria* / genetics
  • Mitochondria* / metabolism
  • Protein Biosynthesis
  • RNA, Messenger / metabolism
  • RNA, Transfer / genetics
  • RNA, Transfer / metabolism
  • tRNA Methyltransferases* / genetics
  • tRNA Methyltransferases* / metabolism

Substances

  • RNA, Messenger
  • RNA, Transfer
  • tRNA Methyltransferases