Tetraspanins in cell stemness and cancer initiation: markers or active players?

Felipe Vences-Catalan; Shoshana Levy

doi:10.1016/j.tcb.2021.10.009

Tetraspanins in cell stemness and cancer initiation: markers or active players?

Trends Cell Biol. 2022 May;32(5):377-379. doi: 10.1016/j.tcb.2021.10.009. Epub 2021 Dec 2.

Authors

Felipe Vences-Catalan¹, Shoshana Levy²

Affiliations

¹ Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, California, CA 94305, USA.
² Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, California, CA 94305, USA. Electronic address: [email protected].

PMID: 34865939
DOI: 10.1016/j.tcb.2021.10.009

Abstract

Tetraspanins mark stem cells and tumor initiating cells. Recent studies in adipose development, intestinal crypt remodeling, and muscle stem cells shed new light on the contribution of tetraspanins and their associated partners in cell fate determination. These studies reveal that these partnerships actively help guide precursor cell fate.

MeSH terms

Cell Differentiation
Humans
Neoplasms*
Neoplastic Stem Cells
Tetraspanins*

Substances

Tetraspanins