Bringing vascularization into glioblastoma in vitro models

Trends Mol Med. 2022 Feb;28(2):84-86. doi: 10.1016/j.molmed.2021.11.001. Epub 2021 Dec 2.

Abstract

Tumor blood vessels create optimal conditions for glioblastoma (GBM) growth and therapy resistance. Therefore, tissue engineering techniques evolved towards allowing its inclusion in preclinical in vitro GBM models. In comparison with conventional ones, less representative of tumor biology, these new tools might significantly improve GBM treatment, contributing to a higher throughput screening in drug research and to the clinical translation of these therapies.

Keywords: glioblastoma; in vitro models; neovascularization; perivascular niche; tissue engineering.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Neoplasms* / drug therapy
  • Brain Neoplasms* / therapy
  • Cell Line, Tumor
  • Glioblastoma* / drug therapy
  • Glioblastoma* / therapy
  • Humans
  • Neovascularization, Pathologic
  • Tissue Engineering