Salmonella "RecAmends" self-healing

Marisa S Egan; Beatrice I Herrmann; Igor E Brodsky

doi:10.1016/j.chom.2021.11.009

Salmonella "RecAmends" self-healing

Cell Host Microbe. 2021 Dec 8;29(12):1729-1731. doi: 10.1016/j.chom.2021.11.009.

Authors

Marisa S Egan¹, Beatrice I Herrmann², Igor E Brodsky³

Affiliations

¹ Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Cellular and Molecular Biology Graduate Group of Pennsylvania Perelman School of Medicine Philadelphia, PA 19104, USA.
² Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA; Cellular and Molecular Biology Graduate Group of Pennsylvania Perelman School of Medicine Philadelphia, PA 19104, USA.
³ Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA; Cellular and Molecular Biology Graduate Group of Pennsylvania Perelman School of Medicine Philadelphia, PA 19104, USA. Electronic address: [email protected].

PMID: 34883061
DOI: 10.1016/j.chom.2021.11.009

Abstract

Persistent bacteria contribute to antibiotic treatment failure, potentially fueling resistance. Persisters must survive host defenses while retaining infective capacity after antibiotic cessation. In this issue of Cell Host and Microbe, Hill et al. identify bacterial RecA as a DNA repair factor that allows intracellular bacteria survival, regrowth, and relapse.

Publication types

Comment

MeSH terms

Anti-Bacterial Agents* / pharmacology
Anti-Bacterial Agents* / therapeutic use
Bacteria*
Salmonella / genetics

Substances

Anti-Bacterial Agents