Drug-Eluting Stents (DES) are commonly used in Coronary angioplasty procedures to reduce the phenomenon of restenosis. Numerical simulations are proven to be a useful tool to the Bioengineering community in computing the mechanical performance of stents. BioCoStent is a research project aiming to develop a DES with retinoic acid (RA) coating, in the frame of which FEAC is responsible for the in silico numerical simulation of the coating's degradation in terms of Finite Element Analysis (FEA). The coatings under study are poly(lactic-co-glycolic acid) (PLGA) and polylactide (PLA). The FEA is based on the Continuum Damage Mechanics (CDM) theory and considers a mechanistic model for polymer bulk degradation of the coatings. The degradation algorithm is implemented on the NX Nastran solver through a user-defined material UMAT subroutine. This paper describes the developed numerical model to compute the degradation of biodegradable coatings on DES. The transient numerical model provides useful insight into the critical areas with regards to the scalar damage of the coatings. The FEA results present a complete degradation of polymers after several weeks.