Fetomaternal microchimerism and genetic diagnosis: On the origins of fetal cells and cell-free fetal DNA in the pregnant woman

Mutat Res Rev Mutat Res. 2021 Jul-Dec:788:108399. doi: 10.1016/j.mrrev.2021.108399. Epub 2021 Nov 18.

Abstract

During pregnancy several types of fetal cells and fetal stem cells, including pregnancy-associated progenitor cells (PAPCs), traffic into the maternal circulation. Whereas they also migrate to various maternal organs and adopt the phenotype of the target tissues to contribute to regenerative processes, fetal cells also play a role in the pathogenesis of maternal diseases. In addition, cell-free fetal DNA (cffDNA) is detectable in the plasma of pregnant women. Together they constitute the well-known phenomenon of fetomaternal microchimerism, which inspired the concept of non-invasive prenatal testing (NIPT) using maternal blood. An in-depth knowledge concerning the origins of these fetal cells and cffDNA allows a more comprehensive understanding of the biological relevance of fetomaternal microchimerism and has implications for the ongoing expansion of resultant clinical applications.

Keywords: Cell-free fetal DNA; Fetomaternal microchimerism; Genetic diagnosis; Non-invasive prenatal testing; Placenta; Pregnancy-associated progenitor cells; Stem cells.

Publication types

  • Review

MeSH terms

  • Amniotic Fluid / cytology
  • Cell Movement
  • Cell-Free Nucleic Acids / genetics
  • Chimerism*
  • Female
  • Humans
  • Noninvasive Prenatal Testing / methods*
  • Pregnancy
  • Pregnancy Complications / diagnosis
  • Pregnancy Complications / genetics*
  • Stem Cells / metabolism
  • Stem Cells / physiology

Substances

  • Cell-Free Nucleic Acids