Acute ST-elevation myocardial infarction in two young women with cystic fibrosis and cystic fibrosis-related diabetes

Sirisha Reddy Thambuluru; Sayyad Kyazimzade; Katherine A Despotes; Deepa Kirk; Jennifer L Goralski

doi:10.1016/j.jcf.2021.11.013

Acute ST-elevation myocardial infarction in two young women with cystic fibrosis and cystic fibrosis-related diabetes

J Cyst Fibros. 2022 Jan;21(1):e44-e47. doi: 10.1016/j.jcf.2021.11.013. Epub 2021 Dec 12.

Authors

Sirisha Reddy Thambuluru¹, Sayyad Kyazimzade², Katherine A Despotes³, Deepa Kirk¹, Jennifer L Goralski⁴

Affiliations

¹ Division of Endocrinology & Metabolism, University of North Carolina, Chapel Hill, NC, United States.
² Department of Internal Medicine, University of North Carolina, Chapel Hill, NC, United States.
³ Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina, Chapel Hill, NC, United States; Division of Pediatric Pulmonology, University of North Carolina, Chapel Hill, NC, United States.
⁴ Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina, Chapel Hill, NC, United States; Division of Pediatric Pulmonology, University of North Carolina, Chapel Hill, NC, United States. Electronic address: [email protected].

PMID: 34911664
DOI: 10.1016/j.jcf.2021.11.013

Abstract

Ischemic heart disease is rarely reported in people with cystic fibrosis (PwCF) despite multiple potential risk factors. Here we report two cases of ST elevation myocardial infarction (STEMI), both in young women with cystic fibrosis (CF) and cystic fibrosis related diabetes (CFRD). These cases illustrate the importance of considering myocardial injury/infarction in the differential diagnosis of patients with CF and chest pain or shortness of breath, and addressing the growing risk of cardiovascular disease (CVD).

Keywords: Coronary Artery Disease; Cystic fibrosis; cystic fibrosis related diabetes; dyslipidemia; myocardial infarction.

Publication types

Case Reports

MeSH terms

Adult
Cardiac Catheterization / methods*
Coronary Angiography
Cystic Fibrosis / complications*
Diabetes Complications*
Diagnosis, Differential
Echocardiography
Female
Humans
Risk Factors
ST Elevation Myocardial Infarction / diagnostic imaging
ST Elevation Myocardial Infarction / therapy*