Neoadjuvant chemotherapy alters peripheral and tumour-infiltrating immune cells in breast cancer revealed by single-cell RNA sequencing

Hanlin Zhou; Guibo Li; Jianhua Yin; Ting Wang; Hong Hu; Tong Li; Qing Zhou; Jintao Hu; Lei Wang; Shichen Dong; Chen Wei; Cuijuan Zhang; Ye Lu; Wenbin Zhou; Chen Huang; Huanming Yang; Dongxian Zhou; Ling Wang; Kui Wu

doi:10.1002/ctm2.621

Neoadjuvant chemotherapy alters peripheral and tumour-infiltrating immune cells in breast cancer revealed by single-cell RNA sequencing

Clin Transl Med. 2021 Dec;11(12):e621. doi: 10.1002/ctm2.621.

Authors

Hanlin Zhou^{1

2

3

4

5}, Guibo Li^{1

2

3

4

5}, Jianhua Yin^{1

2

3}, Ting Wang⁶, Hong Hu⁷, Tong Li^{1

2

3}, Qing Zhou^{1

2}, Jintao Hu⁸, Lei Wang^{1

2

3}, Shichen Dong^{1

2

3}, Chen Wei^{1

9}, Cuijuan Zhang^{1

2

3}, Ye Lu^{1

9}, Wenbin Zhou⁷, Chen Huang⁶, Huanming Yang^{1

10}, Dongxian Zhou⁷, Ling Wang⁶, Kui Wu^{1

2

4}

Affiliations

¹ BGI-Shenzhen, Shenzhen, China.
² BGI College & Henan Institute of Medical and Pharmaceutical Science, Zhengzhou University, Zhengzhou, China.
³ BGI-Henan, BGI-Shenzhen, Xinxiang, China.
⁴ Guangdong Provincial Key Laboratory of Human Disease Genomics, Shenzhen Key Laboratory of Genomics, BGI-Shenzhen, Shenzhen, China.
⁵ Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
⁶ Department of Vascular and Endocrine Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
⁷ Department of Breast Surgery, The Second Affiliated Hospital of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
⁸ Department of Pathology, The Second Affiliated Hospital of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
⁹ College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
¹⁰ Omics team, James D. Watson Institute of Genome Sciences, Hangzhou, China.

No abstract available

Publication types

Letter

MeSH terms

Breast Neoplasms / drug therapy*
Breast Neoplasms / genetics
Breast Neoplasms / physiopathology
Humans
Lymphocytes, Tumor-Infiltrating / drug effects*
Lymphocytes, Tumor-Infiltrating / immunology
Lymphocytes, Tumor-Infiltrating / metabolism
Neoadjuvant Therapy / methods
Neoadjuvant Therapy / standards*
Neoadjuvant Therapy / statistics & numerical data
Sequence Analysis, RNA / methods
Sequence Analysis, RNA / statistics & numerical data
Single-Cell Analysis / methods
Single-Cell Analysis / statistics & numerical data