[Bispecific antibodies in multiple myeloma]

Bull Cancer. 2021 Oct;108(10S):S205-S212. doi: 10.1016/j.bulcan.2021.10.003.
[Article in French]

Abstract

Immunotherapies have recently emerged as potential game changers in the treatment of multiple myeloma (MM). Those include monoclonal antibodies (targeting CD38 or CS1), bispecific antibodies (BsAb, mainly targeting BCMA, GPRC5D or FcRH5), antibody-drug conjugate (mainly targeting BCMA) and CAR-T cells (mainly targeting BCMA). BsAb have the capacity to bind two different antigens, one at the tumor cell surface and one on T cells (CD3), recreating the immune synapse. In this article, we discuss the main clinical data on BsAb in MM, as well as their different constructs and the potential mechanism of resistance.

Keywords: Anticorps bispécifiques; BCMA; Bispecific antibodies in multiple myeloma; Immunothérapie.

Publication types

  • Review

MeSH terms

  • ADP-ribosyl Cyclase 1 / immunology
  • Antibodies, Bispecific / immunology
  • Antibodies, Bispecific / therapeutic use*
  • Antigens, Neoplasm / immunology
  • Drug Resistance, Neoplasm / immunology
  • Humans
  • Immunotherapy / methods*
  • Multiple Myeloma / immunology
  • Multiple Myeloma / therapy*
  • Receptors, Fc / immunology
  • Receptors, G-Protein-Coupled / immunology
  • Signaling Lymphocytic Activation Molecule Family / immunology
  • T-Lymphocytes / immunology

Substances

  • Antibodies, Bispecific
  • Antigens, Neoplasm
  • FCRL5 protein, human
  • GPRC5D protein, human
  • Receptors, Fc
  • Receptors, G-Protein-Coupled
  • SLAMF7 protein, human
  • Signaling Lymphocytic Activation Molecule Family
  • ADP-ribosyl Cyclase 1