Unleashing T cell responses to cancer through removal of intracellular checkpoints

Robert J Salmond

doi:10.1111/imcb.12516

Unleashing T cell responses to cancer through removal of intracellular checkpoints

Immunol Cell Biol. 2022 Jan;100(1):18-20. doi: 10.1111/imcb.12516. Epub 2021 Dec 21.

Author

Robert J Salmond¹

Affiliation

¹ Leeds Institute of Medical Research at St James's, University of Leeds, St James's University Hospital, Leeds, UK.

PMID: 34936141
DOI: 10.1111/imcb.12516

Abstract

In a new study, researchers identified protein tyrosine phosphatase PTP1B as an inhibitor of cytokine receptor signalling and demonstrated that blocking activity or expression of this enzyme unleashes T cell responses to cancer.

MeSH terms

Humans
Neoplasms*
Phosphorylation
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism
Signal Transduction / physiology
T-Lymphocytes* / metabolism

Substances

Protein Tyrosine Phosphatase, Non-Receptor Type 1