A rare presentation of an ACTH-producing high-grade large cell neuroendocrine carcinoma with Cushing's syndrome

Francis Essien; Christine Persaud; David Dado; Rina Eden; Joshua Tate; George Shahin

doi:10.1002/ccr3.5168

A rare presentation of an ACTH-producing high-grade large cell neuroendocrine carcinoma with Cushing's syndrome

Clin Case Rep. 2021 Dec 13;9(12):e05168. doi: 10.1002/ccr3.5168. eCollection 2021 Dec.

Authors

Francis Essien¹, Christine Persaud¹, David Dado², Rina Eden³, Joshua Tate⁴, George Shahin⁵

Affiliations

¹ Department of Internal Medicine David Grant Medical Center Travis Air Force Base Fairfield California USA.
² Division of Nephrology Department of Internal Medicine Keesler Medical Center Keesler Air Force Base Biloxi MS USA.
³ Division of Pathology Department of Internal Medicine Keesler Medical Center Keesler Air Force Base Biloxi MS USA.
⁴ Division of Endocrinology Department of Internal Medicine Keesler Medical Center Keesler Air Force Base Biloxi MS USA.
⁵ Division of Hematology/Oncology Department of Internal Medicine Keesler Medical Center Keesler Air Force Base Biloxi MS USA.

Abstract

High-grade neuroendocrine tumors (HGNET) are rare neoplasms composed of neural and hormonal with only around 42 cases reported in the last 20 years1. Herein, we describe a rare case of pancreatic HGNET, large cell type, associated with a Cushing's syndrome presentation.

Keywords: Cushing's syndrome; chemotherapy; high‐grade neuroendocrine tumors (HGNET); large cell type; pancreatic neuroendocrine tumors (P‐NETs); poor differentiation.

Publication types

Case Reports