Discussion of Research Priorities for Gait Disorders in Parkinson's Disease

Mov Disord. 2022 Feb;37(2):253-263. doi: 10.1002/mds.28883. Epub 2021 Dec 22.

Abstract

Gait and balance abnormalities develop commonly in Parkinson's disease and are among the motor symptoms most disabling and refractory to dopaminergic or other treatments, including deep brain stimulation. Efforts to develop effective therapies are challenged by limited understanding of these complex disorders. There is a major need for novel and appropriately targeted research to expedite progress in this area. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society has charged a panel of experts in the field to consider the current knowledge gaps and determine the research routes with highest potential to generate groundbreaking data. © 2021 International Parkinson and Movement Disorder Society.

Keywords: FOG; Parkinson's disease; balance; freezing; gait; research priorities.

Publication types

  • Review

MeSH terms

  • Dopamine
  • Gait / physiology
  • Gait Disorders, Neurologic* / etiology
  • Gait Disorders, Neurologic* / therapy
  • Humans
  • Parkinson Disease* / complications
  • Parkinson Disease* / therapy
  • Research

Substances

  • Dopamine