Cycloserine did not increase depression incidence or severity at standard dosing for multidrug-resistant tuberculosis

Jeffrey A Tornheim; Zarir F Udwadia; Prerna R Arora; Ishita Gajjar; Nikhil Gupte; Samridhi Sharma; Megha Karane; Namrata Sawant; Nisha Kharat; Alexander J Blum; Shri Vijay Bala Yogendra Shivakumar; Jai B Mullerpattan; Lancelot M Pinto; Tester F Ashavaid; Amita Gupta; Camilla Rodrigues

doi:10.1183/13993003.02511-2021

Cycloserine did not increase depression incidence or severity at standard dosing for multidrug-resistant tuberculosis

Eur Respir J. 2022 Mar 24;59(3):2102511. doi: 10.1183/13993003.02511-2021. Print 2022 Mar.

Authors

Jeffrey A Tornheim¹, Zarir F Udwadia², Prerna R Arora³, Ishita Gajjar³, Nikhil Gupte^{1

4}, Samridhi Sharma³, Megha Karane³, Namrata Sawant³, Nisha Kharat³, Alexander J Blum⁵, Shri Vijay Bala Yogendra Shivakumar⁴, Jai B Mullerpattan⁶, Lancelot M Pinto⁶, Tester F Ashavaid³, Amita Gupta^{1

7}, Camilla Rodrigues⁸

Affiliations

¹ Center for Clinical Global Health Education, Division of Infectious Diseases, Dept of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Dept of Respiratory Medicine, P.D. Hinduja National Hospital and MRC, Mumbai, India [email protected].
³ Dept of Lab Medicine, P.D. Hinduja National Hospital and MRC, Mumbai, India.
⁴ Johns Hopkins University - India office (CCGHE), Pune, India.
⁵ Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁶ Dept of Respiratory Medicine, P.D. Hinduja National Hospital and MRC, Mumbai, India.
⁷ Dept of International Health, Johns Hopkins Bloomberg School of Public Heath, Baltimore, MD, USA.
⁸ Dept of Microbiology, P.D. Hinduja National Hospital and MRC, Mumbai, India.

Abstract

In a longitudinal cohort of MDR-TB patients receiving individualised, DST-based treatment, neither the inclusion of cycloserine in a multidrug regimen nor the dose used (up to 750 mg daily) significantly increased incidence of depression during treatment https://bit.ly/3GtQmOH

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / therapeutic use
Cycloserine*
Depression
Humans
Incidence
Tuberculosis, Multidrug-Resistant* / drug therapy
Tuberculosis, Multidrug-Resistant* / epidemiology

Substances

Antitubercular Agents
Cycloserine

Abstract

Publication types

MeSH terms

Substances

Grants and funding