Role of arachidonic acid lipoxygenase pathway in Asthma

Prostaglandins Other Lipid Mediat. 2022 Feb:158:106609. doi: 10.1016/j.prostaglandins.2021.106609. Epub 2021 Dec 23.

Abstract

The arachidonic acid (AA) metabolism pathways play a key role in immunological response and inflammation diseases, such as asthma, etc. AA in cell membranes can be metabolized by lipoxygenases (LOXs) to a screen of bioactive substances that include leukotrienes (LTs), lipoxins (LXs), and eicosatetraenoic acids (ETEs), which are considered closely related to the pathophysiology of respiratory allergic disease. Studies also verified that drugs regulating AA LOXs pathway have better rehabilitative intervention for asthma. This review aims to summarize the physiological and pathophysiological importance of AA LOXs metabolism pathways in asthma and to discuss its prospects of therapeutic strategies.

Keywords: Airway inflammation; Arachidonic acid; Asthma; Lipoxygenase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arachidonate 5-Lipoxygenase
  • Arachidonate Lipoxygenases
  • Asthma* / drug therapy
  • Humans
  • Leukotrienes
  • Lipoxins*
  • Lipoxygenases

Substances

  • Leukotrienes
  • Lipoxins
  • Arachidonate Lipoxygenases
  • Lipoxygenases
  • Arachidonate 5-Lipoxygenase