In long-term, higher-dose opioid use, dose tapering was linked to overdose and mental health crises

Ann Intern Med. 2022 Jan;175(1):JC11. doi: 10.7326/J21-0005. Epub 2022 Jan 4.

Abstract

Agnoli A, Xing G, Tancredi DJ, et al. Association of dose tapering with overdose or mental health crisis among patients prescribed long-term opioids. JAMA. 2021;326:411-9. 34342618.

Publication types

  • Comment

MeSH terms

  • Analgesics, Opioid / adverse effects
  • Drug Overdose* / drug therapy
  • Drug Overdose* / epidemiology
  • Drug Tapering
  • Humans
  • Mental Health
  • Opioid-Related Disorders* / drug therapy
  • Opioid-Related Disorders* / epidemiology

Substances

  • Analgesics, Opioid