Safety and biocompatibility of a bionic eye: Imaging, intraocular pressure, and histology data

Samuel C Eggenberger; Natalie L James; Cherry Ho; Steven S Eamegdool; Veronika Tatarinoff; Naomi A Craig; Barry S Gow; Susan Wan; Christopher W D Dodds; Donna La Hood; Aaron Gilmour; Shannon L Donahoe; Mark Krockenberger; Krishna Tumuluri; Melville J da Cruz; John R Grigg; Peter McCluskey; Nigel H Lovell; Michele C Madigan; Adrian T Fung; Gregg J Suaning

doi:10.1016/j.dib.2021.107634

Safety and biocompatibility of a bionic eye: Imaging, intraocular pressure, and histology data

Data Brief. 2021 Nov 26:39:107634. doi: 10.1016/j.dib.2021.107634. eCollection 2021 Dec.

Authors

Samuel C Eggenberger¹, Natalie L James², Cherry Ho², Steven S Eamegdool³, Veronika Tatarinoff², Naomi A Craig², Barry S Gow², Susan Wan⁴, Christopher W D Dodds², Donna La Hood^{5

6}, Aaron Gilmour^{1

2}, Shannon L Donahoe⁷, Mark Krockenberger⁷, Krishna Tumuluri^{3

8

9}, Melville J da Cruz^{10

11}, John R Grigg^{3

11}, Peter McCluskey^{3

11}, Nigel H Lovell², Michele C Madigan^{3

6}, Adrian T Fung^{3

8

9}, Gregg J Suaning^{1

2}

Affiliations

¹ School of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, Australia.
² Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia.
³ Save Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health.
⁴ The Westmead Institute for medical research, Westmead, Australia.
⁵ Brien Holden Vision Institute, Sydney, Australia.
⁶ School of Optometry and Vision Science, University of New South Wales (UNSW), Sydney, Australia.
⁷ Veterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, University of Sydney, Sydney, Australia.
⁸ Westmead Clinical School, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
⁹ Department of Ophthalmology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.
¹⁰ Department of Otolaryngology, Westmead Hospital, University of Sydney, Sydney, Australia.
¹¹ Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

Abstract

The data presented here are related and supplementary data to the research article "Implantation and long-term assessment of the stability and biocompatibility of a novel 98 channel suprachoroidal visual prosthesis in sheep" [1]. In Eggenberger et al., nine sheep of the Suffolk (N=2) and Dorper (N=7) breeds were implanted in the left eye with an electrically inactive, suprachoroidal retinal stimulator (Bionic Eye) for durations of up to 100 days. The surgical safety, implant stability and device biocompatibility were assessed. Intraocular pressure measurements, indirect and infrared ophthalmoscopy and optical coherence tomography were performed at fixed time points to evaluate the clinical effects of the surgery and device implantation. Post-mortem eye tissue collection and histology was performed to measure the effects of the intervention at the cellular level. The data, including a comprehensive collection of fundus, infrared, optical coherence tomography and histology images can be used as a reference for comparison with other research, for example, active retinal stimulators. Furthermore, these data can be used to evaluate the suitability of the sheep model, in particular Dorper sheep, for future research.

Keywords: Biocompatibility; Histopathology; Intraocular pressure; Opthalmoscopy; Retina; Visual prosthesis.