Non-coding NOTCH1 mutations in chronic lymphocytic leukemia negatively impact prognosis

Am J Hematol. 2022 Mar 1;97(3):E100-E102. doi: 10.1002/ajh.26457. Epub 2022 Jan 21.

Authors

Fatima Zahra Jelloul¹, Richard K Yang¹, Peng Wang², Sofia Garces¹, Rashmi Kanagal-Shamanna¹, Chi Y Ok¹, Sanam Loghavi¹, Mark J Routbort¹, Zhuang Zuo¹, Cheng Cameron Yin¹, Kristen Floyd¹, Roland L Bassett Jr³, William G Wierda⁴, Nitin Jain⁴, Philip A Thompson⁴, Rajyalakshmi Luthra¹, Leonard Jeffrey Medeiros¹, Keyur P Patel¹

Affiliations

¹ Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
² Department of Pathology, The University of Chicago, Chicago, Illinois, USA.
³ Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
⁴ Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Disease-Free Survival
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
Leukemia, Lymphocytic, Chronic, B-Cell* / mortality
Male
Mutation*
Neoplasm Proteins / genetics*
Receptor, Notch1 / genetics*
Survival Rate

Substances

NOTCH1 protein, human
Neoplasm Proteins
Receptor, Notch1

Grants and funding

P30 CA016672/CA/NCI NIH HHS/United States