Defining the evolutionary and gene regulatory logic of vertebrate neuronal diversity

Luis de la Torre-Ubieta

doi:10.1016/j.neuron.2021.12.013

Defining the evolutionary and gene regulatory logic of vertebrate neuronal diversity

Neuron. 2022 Jan 5;110(1):3-5. doi: 10.1016/j.neuron.2021.12.013.

Author

Luis de la Torre-Ubieta¹

Affiliation

¹ Department of Psychiatry and Biobehavioral Sciences, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: [email protected].

PMID: 34990577
DOI: 10.1016/j.neuron.2021.12.013

Abstract

How is the exquisite cellular complexity of the vertebrate brain achieved? In this issue of Neuron, Closser et al. (2022) reveal that an expanded neuronal gene regulatory landscape may drive evolutionary cellular diversification by providing complex context and cell-specific control of effector genes.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Biological Evolution*
Gene Expression Regulation
Logic
Neurons
Vertebrates* / genetics

Abstract

Publication types

MeSH terms

Grants and funding