Circulating Cell-Free Mitochondrial DNA in Pregnancy

Jessica L Bradshaw; Spencer C Cushen; Nicole R Phillips; Styliani Goulopoulou

doi:10.1152/physiol.00037.2021

Circulating Cell-Free Mitochondrial DNA in Pregnancy

Physiology (Bethesda). 2022 Jul 1;37(4):0. doi: 10.1152/physiol.00037.2021. Epub 2022 Jan 10.

Authors

Jessica L Bradshaw¹, Spencer C Cushen^{1

2}, Nicole R Phillips³, Styliani Goulopoulou^{1

4}

Affiliations

¹ Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
² Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, Texas.
³ Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas.
⁴ Lawrence D. Longo MD Center for Perinatal Biology, Loma Linda University, Loma Linda, California.

Abstract

Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss the temporal changes of ccf-mtDNA during pregnancy and its potential contribution to adverse pregnancy outcomes in pregnancy complications.

Keywords: circulating DNA; gestation; maternal; mitochondria; preeclampsia.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Cell-Free Nucleic Acids* / genetics
Cell-Free Nucleic Acids* / metabolism
DNA, Mitochondrial / genetics
DNA, Mitochondrial / metabolism
Female
Humans
Inflammation / metabolism
Mitochondria* / metabolism
Pregnancy

Substances

Cell-Free Nucleic Acids
DNA, Mitochondrial

Abstract

Publication types

MeSH terms

Substances

Grants and funding