Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2

Cell Res. 2022 Mar;32(3):315-318. doi: 10.1038/s41422-021-00600-y. Epub 2022 Jan 12.

Shuyuan Zhang^#¹, Qingtai Liang^#^{2

3}, Xinheng He⁴, Chongchong Zhao⁵, Wenlin Ren⁶, Ziqing Yang^{2

3}, Ziyi Wang¹, Qiang Ding⁶, Haiteng Deng⁵, Tong Wang⁷, Linqi Zhang^{8

9}, Xinquan Wang¹⁰

¹ The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China.
² Comprehensive AIDS Research Center and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing, China.
³ NexVac Research Center, Tsinghua University, Beijing, China.
⁴ Microsoft Research Asia, Beijing, China.
⁵ Protein Chemistry and Proteomics Facility Technology Center for Protein Research, Tsinghua University, Beijing, China.
⁶ Center for Infectious Disease Research and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing, China.
⁷ Microsoft Research Asia, Beijing, China. [email protected].
⁸ Comprehensive AIDS Research Center and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing, China. [email protected].
⁹ NexVac Research Center, Tsinghua University, Beijing, China. [email protected].
¹⁰ The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China. [email protected].

^# Contributed equally.

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