Effect of hemodialysis on short-term outcomes after colon cancer surgery

PLoS One. 2022 Jan 12;17(1):e0262531. doi: 10.1371/journal.pone.0262531. eCollection 2022.

Abstract

Background: Hemodialysis patients who undergo surgery have a high risk of postoperative complications. The aim of this study was to determine whether colon cancer surgery can be safely performed in hemodialysis patients.

Methods: This multicenter retrospective study included 1372 patients who underwent elective curative resection surgery for colon cancer between April 2016 and March 2020.

Results: Of the total patients, 19 (1.4%) underwent hemodialysis, of whom 19 (100%) had poor performance status and 18 had comorbidities (94.7%). Minimally invasive surgery was performed in 78.9% of hemodialysis patients. The postoperative complication rate was significantly higher in hemodialysis than non-hemodialysis patients (36.8% vs. 15.5%, p = 0.009). All postoperative complications in the hemodialysis patients were infectious type. Multivariate analysis revealed a significant association of hemodialysis with complications (odds ratio, 2.9362; 95%CI, 1.1384-7.5730; p = 0.026).

Conclusion: Despite recent advances in perioperative management and minimally invasive surgery, it is necessary to be aware that short-term complications can still occur, especially infectious complications in hemodialysis patients.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / surgery*
  • Digestive System Surgical Procedures / mortality*
  • Elective Surgical Procedures / mortality*
  • Female
  • Follow-Up Studies
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Postoperative Complications / epidemiology
  • Postoperative Complications / mortality*
  • Prognosis
  • Renal Dialysis / statistics & numerical data*
  • Retrospective Studies
  • Risk Factors
  • Survival Rate
  • Young Adult

Grants and funding

The authors received no specific funding for this work.