Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma: A case report and management of neonatal hypercalcemia: Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma

C Tanné; J-P Pracros; F Dijoud; P-Y Mure; F Bordet; A Duncan; J Bacchetta

doi:10.1016/j.arcped.2021.11.013

Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma: A case report and management of neonatal hypercalcemia: Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma

Arch Pediatr. 2022 Feb;29(2):153-156. doi: 10.1016/j.arcped.2021.11.013. Epub 2022 Jan 14.

Authors

C Tanné¹, J-P Pracros², F Dijoud³, P-Y Mure⁴, F Bordet⁵, A Duncan⁶, J Bacchetta⁷

Affiliations

¹ Pediatric and Neonatology Unit, Hôpitaux du Pays du Mont Blanc, Sallanches, France; Reference Center for Rare Diseases of Calcium and Phosphate, Reference Center for Rare Renal Diseases, ORKID, OSCAR and ERK-Net Networks for Rare Diseases, Pediatric Nephrology, Rheumatology and Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France. Electronic address: [email protected].
² Department of Pediatric Radiology, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France.
³ Institut de Pathologie Multisite, Groupement Hospitalier Est, Hospices Civils de Lyon, France, Université Claude Bernard Lyon 1, France.
⁴ Service de Chirurgie Viscérale Pédiatrique, Groupement Hospitalier Est, Hospices Civils de Lyon, France; Faculté de Médecine Lyon Est, Université Lyon 1, 69008, Lyon, France.
⁵ Pediatric Intensive Care, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, Bron, France.
⁶ Reference Center for Rare Diseases of Calcium and Phosphate, Reference Center for Rare Renal Diseases, ORKID, OSCAR and ERK-Net Networks for Rare Diseases, Pediatric Nephrology, Rheumatology and Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France.
⁷ Reference Center for Rare Diseases of Calcium and Phosphate, Reference Center for Rare Renal Diseases, ORKID, OSCAR and ERK-Net Networks for Rare Diseases, Pediatric Nephrology, Rheumatology and Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France; Faculté de Médecine Lyon Est, Université Lyon 1, 69008, Lyon, France.

PMID: 35039190
DOI: 10.1016/j.arcped.2021.11.013

Abstract

Congenital mesoblastic nephroma is a rare pediatric renal tumor and has been reported in patients presenting with palpable abdominal mass, arterial hypertension, hematuria, polyuria, or hypercalcemia. Here we present the case of a 1-month-old neonate with suspected parathyroid hormone (PTH)-related peptide (PTH-rp)-mediated severe hypercalcemia revealing congenital mesoblastic nephroma. Preoperatively, hypercalcemia was corrected with hydration, furosemide, pamidronate, and low-calcium infant formula. Unilateral nephrectomy led to the resolution of hypercalcemia, transient hyperparathyroidism, and transient vitamin D and mineral supplementation. We conclude that congenital mesoblastic nephroma can secrete PTH-rp that can cause severe hypercalcemia.

Keywords: Congenital mesoblastic nephroma; Hypercalcemia; Hypercalcemia management; PTH-rp; Pediatrics.

Publication types

Case Reports

MeSH terms

Calcium / blood
Female
Food, Fortified
Furosemide / therapeutic use
Humans
Hypercalcemia / congenital*
Hypercalcemia / etiology
Hypercalcemia / therapy
Hypertension
Infant Formula
Infant, Newborn
Kidney Neoplasms / complications
Kidney Neoplasms / congenital*
Kidney Neoplasms / surgery
Nephrectomy
Nephroma, Mesoblastic / complications
Nephroma, Mesoblastic / congenital*
Nephroma, Mesoblastic / surgery
Pamidronate / therapeutic use
Treatment Outcome

Substances

Furosemide
Pamidronate
Calcium