Chemoproteomic profiling reveals celastrol as a potential modulator of cholesterol signaling

Yiyun Geng; Jingyuan Xu; Weichao Li; Qing Li; Chenjinxin Shen; Zhangshuang Deng; Yiqing Zhou

doi:10.1039/d1cc05986f

Chemoproteomic profiling reveals celastrol as a potential modulator of cholesterol signaling

Chem Commun (Camb). 2022 Feb 8;58(12):1914-1917. doi: 10.1039/d1cc05986f.

Authors

Yiyun Geng¹, Jingyuan Xu¹, Weichao Li², Qing Li^{1

3}, Chenjinxin Shen¹, Zhangshuang Deng³, Yiqing Zhou^{1

2}

Affiliations

¹ School of Biotechnology and Food Engineering, Changshu Institute of Technology, Suzhou 215500, China. [email protected].
² CAS Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
³ College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China.

PMID: 35040838
DOI: 10.1039/d1cc05986f

Abstract

We report a quantitative chemoproteomic approach that utilizes a clickable photoreactive probe for global profiling of celastrol targets, which may significantly improve the current understanding of celastrol's mode of action.

MeSH terms

Apoptosis / drug effects
Cholesterol / metabolism*
Humans
MCF-7 Cells
Pentacyclic Triterpenes / pharmacology*
Proteomics / methods*
Signal Transduction / drug effects*

Substances

Pentacyclic Triterpenes
Cholesterol
celastrol